| 摘要 |
<p>PROBLEM TO BE SOLVED: To obtain the subject compound useful as an intermediate for pharmaceuticals in high optical yield by the asymmetric hydrogenation reaction using a transition metal-optically active phosphine complex. SOLUTION: An optically active carboxylic acid of formula II is produced by the asymmetric hydrogenation of (A) aβ,γ-unsaturated carboxylic acid of formula I (R<1> is H, amino, acetylamino, t-butoxycarbonylamino or p- cyanobenzoylamino; X is O or CH2 ) using (B) a transition metal-optically active phosphine complex as a catalyst. The transition metal is preferably ruthenium, rhodium or iridium, especially ruthenium. The optically active phosphine in the component B is preferably a binaphthyl compound of formula III (R<2> is phenyl or cyclohexyl which may have methyl, t-butyl or methoxy substituent; X is H, amino, acetylamino, etc.).</p> |
