Quinazoline derivatives as antitumor agents

摘要

The invention concerns quinazoline derivatives of the formula I wherein X¹ is a direct link or a group such as CO, C(R²)₂ and CH(OR²); wherein Q¹ is phenyl, naphthyl or a 5- or 6-membered heteroaryl moiety and Q¹ optionally bears up to 3 substituents; wherein m is 1 or 2 and each R¹ may be a group such as hydrogen, halogeno and trifluoromethyl; and wherein Q² may be phenyl or a 9- or 10-membered bicyclic heterocyclic moiety and Q² optionally bears up to 3 substituents; or a pharmaceutically-acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and the use of their receptor tyrosine kinase inhibitory properties in the treatment of proliferative disease such as cancer.