| 摘要 |
PCT No. PCT/EP97/00611 Sec. 371 Date Aug. 12, 1998 Sec. 102(e) Date Aug. 12, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/30154 PCT Pub. Date Aug. 21, 1997A complete cDNA sequence (SEQ ID NO: 1) is described, which codes for a 14 kDa protein (SEQ ID NO: 2) obtainable from goat liver. This protein shows marked anti-neoplastic activity both in vitro and in vivo. The serum of animals immunized with this protein displays cytotoxic activity against human tumor cell lines. The cDNA sequence of the invention may be obtained by procedures involving, among other things, the use of degenerate oligonucleotides. |
