| 摘要 |
PROBLEM TO BE SOLVED: To obtain a medicine having an action on the inhibition of adhesion and infiltration of leukocyte and effective for preventing and treating inflammation, especially progressive chronic inflammation. SOLUTION: This medicine contains a samaderin derivative of the formula [R<1> is H, OH; R<2> is O, etc.; R<3> is H, O; R<4> is H, OH; R<5> is CH3 , etc.; R<6> is OH; R<7> is H or OH; R<8> , R<9> are each a group for together forming a group of the formula: -C(R<10> )H-COO-; or R<6> , R<7> are each a group for together forming a group of the formula: -O-CO-; R<8> is H; R<9> is O; R<10> is H, OH, etc.; the dotted line is a single bond or a double bond when R<2> is O, R<5> is CH3 ; when R<7> is OH and when R<8> and R<9> are each a group for together forming a group of the formula: -C(OH)H-COO-, R<4> is OH] as an active ingredient. The compound of the formula can be obtained by isolating a plant belonging to the family Simaroubaceae and subsequently purifying the isolated compound. The compound of the formula is orally administered at a daily dose of 0.1-200mg/adult by one to several portions or intravenously administered at a daily dose of 0.1-100 mg/adult by one to several portions. |
