发明名称 |
10-(1-hydroxyethyl)-11-oxo-1-azatri-cyclo 7.2.0.03,8 -undec-2-en-2-carboxylsyrederivater. |
摘要 |
<p>Compounds of the general formula (I) <CHEM> in which:- R1 represents a hydroxyl protecting group; and R2 represents a hydrogen or halogen atom, an azido group, a C1-3 alkyl group, a group (CH2)mOR3 wherein m is zero or one and R3 represents a hydrogen atom or a hydroxyl protecting group, an azidoethoxy group, a protected hydroxyethoxy group or a group XR4 in which X is an oxygen atom or the group S(O)n in which n is zero, 1 or 2 and R4 represents a C1-5alkyl, C3-7 cycloalkyl or phenyl group or when X is oxygen or sulphur then R4 may also represent the group AlkNR5R6 in which Alk represents a C2-6 straight or branched alkylene chain and R5 and R6 independently represent a hydrogen atom or C1-4alkyl group or R5 and R6 together with the nitrogen atom to which they are attached form a pyrrolidino or piperidino ring or the group NR5R6 represents a protected amino group, or R2 represents the group (CH2)mNR7R8 in which m is zero or 1 and R7 and R8 independently represent a hydrogen atom or a C1-4alkyl group or NR7R8 represents a protected amino group, or R2 and the carbon atom to which it is attached represent a keto group or a ketal derivative thereof; and acid addition salts of such compounds containing basic centres.</p> |
申请公布号 |
DK0416953(T3) |
申请公布日期 |
1997.09.01 |
申请号 |
DK19900309848T |
申请日期 |
1990.09.07 |
申请人 |
GLAXO WELLCOME S.P.A. |
发明人 |
TAMBURINI, BRUNO;PERBONI, ALCIDE;ROSSI, TINO;DONATI, DANIELE;ANDREOTTI, DANIELE;GAVIRAGHI, GIOVANNI;CARLESSO, ROBERTO;BISMARA, CLAUDIO |
分类号 |
C07D487/04;A61K31/395;A61K31/397;A61K31/40;A61K31/407;A61P31/04;C07C45/71;C07C49/753;C07D205/08;C07D477/00;C07D487/00;C07F7/18;(IPC1-7):C07D477/00 |
主分类号 |
C07D487/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|