SUBSTITUTED THIOPHENYLALKENYLCARBOXYLIC ACID GUANIDINES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENT OR DIAGNOSIS AGENT, AS WELL AS MEDICAMENT CONTAINING THEM.

摘要

The invention discloses substituted thiophenylalkenyl-carboxylic acid guanidines of formula I wherein R(1) to R(5) are as described in the claims. The compounds of the present invention are particularly active anti-arrhythmic medicaments comprising a cardioprotective component and particularly suitable for prophilaxis and treatment of infarcts, as well as for the treatment of angina pectoris, also strongly inhibiting or reducing, in a preventive way, pathophysiological processes in ischaemias induced lesions, specially in ischaemias induced heart arrhythmias.