发明名称 |
Process for the preparation of 10-(2-propynyl)ester-4-ene-3,17-dione |
摘要 |
<p>This invention relates to a process for the preparation of 10-(2-propynyl)-estr-4-ene-3,17-dione, whereby this compound is synthesized utilizing ketals prepared from the addition of 2,2-dimethyl-1,3-propanediol to the starting compound, 19-norandrost-5(10)-ene-3,17-dione (NAD). A new process for the addition of the propynyl group to steroid epoxides by means of higher order cuprates is also described herein.</p> |
申请公布号 |
GR3023380(T3) |
申请公布日期 |
1997.08.29 |
申请号 |
GR19970401033T |
申请日期 |
1997.05.09 |
申请人 |
MERRELL PHARMACEUTICALS INC. |
发明人 |
WHITTEN, JEFFREY P.;BENSON, HARVEY D.;RAND, CYNTHIA L. |
分类号 |
A61K31/565;A61P43/00;C07J1/00;C07J21/00;C07J51/00;C07J71/00;(IPC1-7):C07J1/00 |
主分类号 |
A61K31/565 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|