3-Sulphatoxy-oestra-tri:ene alkali metal salt production

摘要

The invention concerns a method of producing 3-sulfanato-oxy-estra-1,3,5(10)-trien derivates of the general formula (I) where the bonds marked with --- symbolize three single bonds, two single bonds and a double bond or two conjugated double bonds, X means a carbonyl group, an hydroxy-methylene group, an alkoxy-methylene group with two to six carbon atoms in the alkoxy residue, a benzyl oxymethylene group, an acyl oxymethylene group with up to eight carbon atoms in the acyl residue or an alkylene dioxymethylene group with two to six carbon atoms in the alkylene residue, and Z<+> represents an alkali-metal cation, by reacting a 3-hydroxy-estra-1,3,5(10)-trien derivate in the presence of an alkali-metal alcoholate with a sulphur trioxide-pyridine complex.