POSSIBLY SUBSTITUTED 8-CYANO-1-CYCLOPROPYL-7-(2,8-DIAZABICYCLO-[4.3.0]-NONAN-8-YL)-6-FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLIN CARBOXYLIC ACIDS AND THEIR DERIVATIVES

摘要

The present invention relates to novel possibly substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo-(4.3.0)-onan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolin carboxylic acids and their derivatives of the general formula (I) in which R1 is hydrogen, C1-C4 alkyl possibly substituted by hydroxy, methoxy, amino, methylamino or dimethylamino or (5-methyl-2-oxo-1,3-dioxol-4-yl)-methyl, R2 is hydrogen, benzyl, C1-C3 alkyl, (5-methyl-2-oxo-1,3-dioxol-4-yl)-methyl, radicals of the structures -CH=CH-COOR3, -CH2CH2COOR3, -CH2CH2CN, CH2CH2COCH3, -CH2COCH3, where R3 is methyl or ethyl, or a radical of the general structure R4-(NH-CHR5-CO)n-, in which R4 is hydrogen, C1-C3 alkyl or the radical -COO-tert.-butyl, R5 is hydrogen, C1-C4 alkyl, hydroxyalkyl, aminoalkyl, thioalkyl, carboxyalkyl or benzyl and n = 1 or 2, and Y is oxygen or sulplur. The invention further concerns the process for their production and their use in anti-bacterial agents.