| 摘要 |
Pharmaceutical compositions that comprise compounds of this formula (see fig. I) (wherein A is CH2 or NR; R is H or alkyl; B, D and E are each CH or N; Y is a cyclic group such as phenyl; Z1 is a divalent group such as -O-CH2CH2-; G is an optionally substituted amino such as piperidino or pyrrolidino; and e is 0, 1 or 2) are useful for treating or preventing Alzheimer's disease, premenstrual syndrome, perimenopausal syndrome, a deficiency of thrombomodulin, uterine fibrosis, excessive myeloproxidase activity, excessive thrombin, autoimmune disease, reperfusion damage of ischemic myocardium and insufficient testosterone.
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