| 摘要 |
The invention relates to crystallized apopain, the use of that structure to solv e the structure of apopain homologues and other crystal forms of apopain, mutants and co-complexes of apopain, and the use of the apopai n structure and that of its homologues, mutants, and co-complexes to design modulators of apopain.
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| 申请人 |
RUEL, REJEAN;MERCK FROSST CANADA INC.;MERCK & CO., INC.;GALLANT, MICHEL;FAZIL, KIMBERLY A.;VAILLANCOURT, JOHN P.;RASPER, DITA M.;LABELLE, MARC;GAREAU, YVES;NICHOLSON, DONALD W. |
发明人 |
RUEL, REJEAN;GALLANT, MICHEL;FAZIL, KIMBERLY A.;VAILLANCOURT, JOHN P.;RASPER, DITA M.;BECKER, JOSEPH W.;PETERSON, ERIN P.;LABELLE, MARC;GAREAU, YVES;NICHOLSON, DONALD W.;THORNBERRY, NANCY A.;ROTONDA, JENNIFER |
