| 摘要 |
New compounds, designated WF 2015 A and B, are disclosed and which have the physicochemical characteristics described herein, are the following: (1) For WF 2015 A a) Molecular weight : 410 [FAB-MS : m/z 411 (M+H)] b) Elemental analysis : C 64.55; H 8.06; O 27.39 (by difference) c) Optical rotation: [ alpha ]23_D = -52 DEG (C=1.0, CH3OH) (2) For WF 2015 B : a) Molecular weight : 447 [FAB-MS : m/z 469 (M+Na)] b) Elemental analysis : C 58.03; H 7.94; Cl 7.31; O 26.72 (by difference) c) Optical rotatation : [ alpha ]23_D - 248 DEG (C=2.0, CHCl3) A process for producing these compounds by culturing a WF 2015 A and/or WF 2015 B producing strain belonging to the genus Scolecobasidium in a nutrient medium is also provided. The compounds WF 2015 A and B have immunosuppressing and anti-tumour activities, and pharmaceutical compositions comprising these compounds are described. |
