发明名称 |
Lymphotoxin- beta , lymphotoxin- beta complexes, pharmaceutical preparations and therapeutic uses thereof |
摘要 |
This invention relates to lymphotoxin- beta , a lymphocyte membrane type protein. This protein is found on the surface of a number of cells, including phorbol ester (PMA) stimulated T cell hybridoma II-23.D7 cells. This invention also relates to complexes formed between lymphotoxin- beta and other peptides such as lymphotoxin- alpha and to complexes comprising multiple subunits of lymphotoxin- beta . These proteins and complexes are useful in holding LT- alpha formed within the cell on the cell surface where the LT- alpha /LT beta complex may act as an inflammation regulating agent, a tumor growth inhibiting agent, a T cell inhibiting agent, a T cell activating agent, an autoimmune disease regulating agent, or an HIV inhibiting agent. Furthermore, the antitumor activity of the LT- alpha /LT- beta complex may be delivered to tumor cells by tumor infiltrating lymphocytes (TILs) transfected with the gene for LT- beta .
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申请公布号 |
US5661004(A) |
申请公布日期 |
1997.08.26 |
申请号 |
US19950484272 |
申请日期 |
1995.06.07 |
申请人 |
BIOGEN, INC.;UNIVERSITY OF CALIFORNIA |
发明人 |
BROWNING, JEFFREY;WARE, CARL F. |
分类号 |
A61K35/14;A61K38/00;A61K39/395;A61K45/00;A61P29/00;A61P31/18;A61P35/00;A61P37/00;A61P37/02;A61P43/00;C07K1/22;C07K14/00;C07K14/52;C07K14/525;C07K14/705;C07K14/725;C07K16/00;C07K16/24;C07K16/28;C07K19/00;C12N5/10;C12N15/09;C12N15/12;C12P21/02;(IPC1-7):C12N15/00;C12N15/11;C12N15/85 |
主分类号 |
A61K35/14 |
代理机构 |
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地址 |
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