Fermentation method and fermentor

摘要

An improved method and fermentor for aerobic production of microbial cells and/or cell metabolites, having at least one ascending flow chambers and at least one descending flow chamber. The fermentor is especially useful in conducting high cell density fermentation processes which involves the controlled addition of an antifoam agent, for maintaining a predetermined and relatively high gas holdup within the fermentor or by release of the constituents of the microbial cells into the fermentor.