| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject agent containing a specific piperazine derivative as an active component and effective for protecting nerve cell from the nerve cell disorder caused by aging, Alzheimers disease, depression, schizophrenia, etc. SOLUTION: This agent contains a compound of formula I (R<1> and R<2> are each H or a halogen; R<3> is H, an alkyl or an acyl; R<4> is H, an alkyl, an acyl, an alkylsulfonyl, etc.; Ar is phenyl or an aromatic heterocyclic group which may have substituent such as a halogen, an alkyl, an alkoxy or nitro) as an active component. Especially preferable examples of the compound of formula I are 1-[4-(4,4-bisfluorophenyl)butyl]-4-(2-hydroxy-3-phenylaminopropyl)pipe razine of formula II, (-)-1-[4-(4,4-bisfluorophenyl)butyl]-4-(2-hydroxy-3-phenylaminopropyl) piperazine of formula III, etc. |
