发明名称 |
ATRIAL HYPOTENSIVE PEPTIDE HAVING 46 AMINO ACIDS |
摘要 |
An atrial natriuretic peptide having profound natriuretic, diuretic and hypotensive effects, characterized by a 46 amino acid residue sequence: Ser-Gln-Asp-Ser-Ala-Phe-Arg-Ile-Gln-Glu-Arg-Leu-Arg-Asn-Ser-Lys-Met-Ala-His-Ser-Ser-Ser-Cys-Phe-Gly-Gln-Lys-Ile-Asp-Arg-Ile-Gly-Ala-Val-Ser-Arg-Leu-Gly-Cys-Asp-Ile-Leu-Leu-Ile-Ala-Gln, having a disulphide bond between the cysteine residues which may be extracted from mammalian heart atria is described. A synthetic 30 amino acid residue peptide corresponding to residues 17-46 of the above sequence has also been prepared and shown to have similar biological activity.
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申请公布号 |
CA1339388(C) |
申请公布日期 |
1997.08.26 |
申请号 |
CA19880570432 |
申请日期 |
1988.06.24 |
申请人 |
QUEEN'S UNIVERSITY AT KINGSTON |
发明人 |
JENNINGS, DONALD B.;FLYNN, THOMAS G. |
分类号 |
A61K38/22;C07K14/58;G01N33/53;G01N33/74;(IPC1-7):C07K14/58 |
主分类号 |
A61K38/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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