| 摘要 |
PROBLEM TO BE SOLVED: To produce an optically active substance of the subject compound by reacting an optically active substance of an α-phenylalkylamine with an α-phenyl alkyl ketone, and the racemic substance by reacting the obtained optically active substance with an alkali metal alkoxide. SOLUTION: An optically active substance or a racemic substance of N-(α- alkylbenzylidene)-α-phenylalkylamine of formula I (R1 is a lower alkyl; R2 is H, a halogen, a lower alkyl, a haloalkyl or a lower alkoxy; X is H, a halogen, a lower alkyl, a haloalkyl or a lower alkoxy; the mark * indicates an asymmetric carbon). An optically active substance of a compound of formula I is obtained by subjecting an optically active substance of α-phenylalkylamine of formula II to a dehydration condensation reaction with an α-phenyl alkyl ketone of formula III in the presence of a catalyst (e.g. zinc chloride) in a solvent (e.g. toluene). Subsequently, the obtained optically active substance is treated with an alkali metal alkoxide (e.g. potassium t-butoxide) in the coexistence of dimethyl sulfoxide to obtain the racemic substance of the compound of formula I. |
