发明名称 |
KOHIVKOTAIKAHENRYOIKIOKOODOSURUIDENSHIDANPENOYOBIKORERAOMOCHIITEHATSUGENSARETAKOHIVKIMERAKOTAINARABINISONOSEIHO |
摘要 |
<p>Described are novel chimeric anti-human immunodeficiency virus (HIV) antibodies which comprise a constant region derived from human antibody and variable region derived from mouse monoclonal antibody, gene fragments coding for the variable region the H and L chain of chimeric anti-HIV antibodies which are effective for expression of chimeric anti-HIV antibodies having an HIV-neutralizing activity, a transformant where such gene fragments are incorporated, chimeric anti-HIV antibodies expressed therefrom and a process for their preparation. The chimeric anti-HIV antibodies of the present invention show anti-HIV neutralizing activity and are useful for the diagnosis, treatment and prevention of acquired immunodeficiency syndrome (AIDS) caused by HIV without side effects such as anaphylactic shock or serum sickness.</p> |
申请公布号 |
JP2646007(B2) |
申请公布日期 |
1997.08.25 |
申请号 |
JP19880171385 |
申请日期 |
1988.07.08 |
申请人 |
KAGAKU OYOBI KETSUSEI RYOHO KENKYUSHO |
发明人 |
MAEDA HIROAKI;EDA YASUYUKI;KURUMI KAZUHIKO;TOKYOSHI YUKIO;MATSUSHITA SHUZO;HATSUTORI TOSHIO;TAKATSUKI KYOSHI |
分类号 |
C12P21/08;A61K38/00;A61K39/42;A61P31/12;C07K16/10;C12N5/10;C12N15/09;C12R1/91;(IPC1-7):C12P21/08 |
主分类号 |
C12P21/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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