RECEPTEUR NUCLEAIRE DE GLUCOCORTICOIDES MODIFIE, FRAGMENTS D'ADN CODANT POUR LEDIT RECEPTEUR ET PROCEDES DANS LESQUELS ILS SONT MIS EN OEUVRE

摘要

A DNA fragment coding for a modified nuclear glucocorticoid receptor, particularly one mutated in the region coding for the ligand binding domain, so that receptor activity is more strongly inducible by a synthetic glucocorticoid ligand than by a natural glucocorticoid ligand, is disclosed. A recombination system inducible in mammals by means of a fusion protein produced between a recombinase and the binding domain of the ligand derived from the modified glucocorticoid receptor of which the activity is more strongly inducible by synthetic glucocorticoids than by natural glucocorticoids, is also disclosed.