发明名称 Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
摘要 Disclosed are nitrosated and nitrosylated alpha -adrenergic receptor antagonists, compositions of an alpha -adrenergic receptor antagonist ( alpha -antagonist), which can optionally be substituted with at least one NO or NO2 moiety, and a compound that donates, transfers or releases nitric oxide as a charged species, i.e., nitrosonium (NO+) or nitroxyl (NO-), or as the neutral species, nitric oxide (NO+574 ); and uses for each of them in treating human male impotence or erectile dysfunction.
申请公布号 AU1756297(A) 申请公布日期 1997.08.22
申请号 AU19970017562 申请日期 1997.01.28
申请人 NITROMED, INC. 发明人 DAVID S GARVEY;JOSEPH D. SCHROEDER;INIGO SAENZ DE TEJADA
分类号 C07D295/08;A61K31/00;A61K31/22;A61K31/222;A61K31/415;A61K31/4164;A61K31/4178;A61K31/475;A61K31/495;A61K31/505;A61K31/506;A61K31/517;A61K38/00;A61P15/00;A61P15/10;C07C217/60;C07C311/37;C07C381/00;C07D211/62;C07D233/24;C07D239/95;C07D401/04;C07D405/12;C07D459/00;C07D487/04 主分类号 C07D295/08
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