发明名称 |
Method of inactivation of ras subfamily proteins and agents therefor |
摘要 |
A method of treating a disorder characterized by an activating mutation in a Ras proto-oncogene, comprising contacting cells of a patient suffering from the disorder with a protein having the toxic activity of Clostridium sordellii toxin LT under conditions favoring inactivation of Ras by glucosylation of Ras' threonine 35 in said cell. The protein preferably is an immunotoxin that contains as a toxic domain the catalytic domain of toxin LT. |
申请公布号 |
AU1598297(A) |
申请公布日期 |
1997.08.22 |
申请号 |
AU19970015982 |
申请日期 |
1997.01.31 |
申请人 |
BOEHRINGER MANNHEIM GMBH |
发明人 |
CHRISTOPH VON EICHEL-STREIBER;PATRICE BOQUET;MONICA THELESTAM |
分类号 |
A61K38/45;A61K47/48;A61K48/00;C07K16/46;C07K19/00;C12N9/10 |
主分类号 |
A61K38/45 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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