NUCLEOTIDES AND PEPTIDES CORRESPONDING TO THE CANINE IgE HEAVY CHAIN CONSTANT REGION AND RELATED METHODS

摘要

Recombinant DNA molecules encoding complete canine IgE heavy chain constant region and the DNA sequence for all six exons of canine IgE are disclosed. The canine IgE heavy chain constant region DNA sequence was isolated using a nested walking procedure that is also disclosed. Also disclosed are peptides encoded by said sequences, including recombinant canine IgE heavy chain peptides produced by prokaryotic or eukaryotic cells. Such peptides are used in methods to treat the manifestation of allergy in dogs. Disclosed are antibodies that bind to peptides disclosed herein, as well as such antibodies for use to treat the manifestations of allergy in dogs.