METHOD OF TREATING LIVER DISORDERS

摘要

A method for enhancing ureagenesis in a subject, preferably a mammal, in need thereof is provided. The method involves administering to the mammal an effective amount of a recombinant virus which expresses in vivo at least one urea cycle enzyme. The method also may involve administration of additional recombinant adenoviruses expressing other of the urea cycle enzymes or a single recombinant adenovirus expressing more than one enzyme. The method also includes a step of administering an immune modulator with the recombinant virus.