THERAPEUTIC AGENT FOR KIDNEY DISEASES

摘要

A therapeutic agent for kidney diseases which comprises as the active ingredient a quinazoline derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R<1> represents hydrogen, lower alkyl, alkenyl, aralkyl, etc.; R<2>, R<3>, R<4>, and R<5> may be the same or different and each represents hydrogen, lower alkyl, lower alkoxy, lower alkanoyl, etc.; R<6>, R<7>, R<8>, and R<9> may be the same or different and each represents hydrogen, lower alkyl, lower alkoxy, aralkyloxy, lower alkanoyloxy, etc., or adjacent two of these may be bonded to each other to thereby form methylenedioxy, etc.; R<10> represents hydrogen, lower alkyl, etc.; R<11> and R<12> may be the same or different and each represents hydrogen, lower alkyl, cycloalkyl, phenyl, aralkyl, etc., or R<11> and R<12> may be bonded to each other to thereby form a heterocycle with the nitrogen atom; and n is 0, 1, or 2. The therapeutic agent is useful for the prevention or treatment of kidney diseases such as nephritis and diabetic nephropathy.