DERIVATIVES OF ANTIBIOTIC GE2270 FACTORS C2a, D2 AND E

摘要

Mono- or di-substituted derivatives of GE2270 factors C2a, D2 and E of general formula (I), wherein W represents a moiety of formula (a), (b) or (c), R<1> and R<2> representing a variety of substituents, X<1> is methyl, X<2> is a -CH2-W<1> moiety and X<3> is methylamino or amino, or X<1> is a -CH2-W<1> moiety, X<2> is methoxymethylene and X<3> is methylamino, with the proviso that when X<3> is amino, then W must be 2-(aminocarbonyl)-pyrrolidinyl; with the further proviso that when W is 2-(aminocarbonyl)-pyrrolidinyl, then W<1> cannot be hydroxy; and the pharmaceutically acceptable salts thereof. The mono- or di-substituted derivatives of antibiotic GE 2270 of formula (I) are antimicrobial agents mainly active against gram positive bacteria.