LIPIDS AND THEIR USE, FOR EXAMPLE, IN LIPOSOMES

摘要

The invention concerns lipids suitable for the transport of biologically active substances or molecules in cells. A preferred lipid is L-lysine-bis-(O,O'-cis-9-octadecenoyl- beta -hydroxyethyl) amide dihydrochloride or one of its optical isomers. In addition, the invention concerns complexes of such lipids with polyanions such as DNA and RNA, and ternary complexes of the lipids described with polyanions and polycations. Finally, the invention concerns liposome formulations made from biologically active substances and the lipids described, as well as methods of transporting polyanions, polycations or biologically active substances through biological membranes by means of these lipids.