发明名称 |
Mammalian methadone-specific opioid receptor gene and uses |
摘要 |
The present invention relates to a novel mammalian methadone-specific opioid receptor protein and genes that encode a such protein. The invention is directed toward the isolation, characterization and pharmacological use of mammalian methadone-specific opioid receptor proteins. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to the rat homologue or the mammalian methadone-specific opioid receptor gene. Also provided are recombinant expression constructs capable of expressing the mammalian methadone-specific opioid receptor genes of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the mammalian methadone-specific opioid receptor proteins encoded therein. The invention also provides methods for screening compounds in vitro that are capable of binding to the mammalian methadone-specific opioid receptor proteins of the invention, and further characterizing the binding properties of such compounds in comparison with known opioid receptor agonists and antagonists.
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申请公布号 |
US5658783(A) |
申请公布日期 |
1997.08.19 |
申请号 |
US19930149093 |
申请日期 |
1993.11.08 |
申请人 |
STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY, A NON-PROFIT ORGANIZATION |
发明人 |
GRANDY, DAVID K.;BUNZOW, JAMES R.;CIVELLI, OLIVIER |
分类号 |
A61K39/00;C07K14/705;C12N15/12;(IPC1-7):C12N15/12;C12N5/10 |
主分类号 |
A61K39/00 |
代理机构 |
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