| 发明名称 |
Aromatic heterocyclic derivatives as enzyme inhibitors |
| 摘要 |
The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
|
| 申请公布号 |
US5658930(A) |
申请公布日期 |
1997.08.19 |
| 申请号 |
US19950481660 |
申请日期 |
1995.06.07 |
| 申请人 |
CORVAS INTERNATIONAL, INC. |
发明人 |
TAMURA, SUSAN YOSHIKO;SEMPLE, JOSEPH EDWARD;RIPKA, WILLIAM CHARLES;ARDECKY, ROBERT JOHN;GE, YU;CARPENTER, STEPHEN H.;BRUNCK, TERENCE K. |
| 分类号 |
A61K38/00;C07D211/56;C07D211/76;C07D213/75;C07D239/46;C07D239/54;C07D239/545;C07D401/12;C07K5/06;C07K5/078;(IPC1-7):A61K31/445;A61K31/505;C07D213/64;C07D233/32;C07D233/40 |
主分类号 |
A61K38/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
