METHODS OF INHIBITING LEADERLESS PROTEIN EXPORT USING CARDIAC GLYCOSIDES OR AGLYCONES THEREFROM AND DERIVATIVES

摘要

This invention provides methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a cardiac glycoside or aglycone derivative. Leaderless proteins include FGF-1, FGF-2, IL-1 alpha , IL-1 beta and factor XIIIa. These methods are useful in treatment of conditions, including tumors and diabetes.