HISTAMINE H3 RECEPTOR LIGANDS

摘要

Compounds of formula (I) or (II) wherein R<1> is C4 to C20 hydrocarbyl (in which one or more hydrogen atoms may be replaced by halogen, and up to three carbon atoms may be replaced by oxygen, nitrogen or sulphur atoms, provided that R<1> does not contain an -O-O- group), R<2> is H or C1 to C3 alkyl, m is from 1 to 15, n is from 2 to 6, each X group is independently (a), or one X group is -N(R<4>)-, -O- or -S- and the remaining X groups are independently (a), wherein R<3> is H, C1 to C6 alkyl, -CO2R<5>, -CONR<5>2, -CR<5>2OR<6> or -OR<5> (in which R<5> and R<6> are H or C1 to C3 alkyl), and R<4> is H or C1 to C6 alkyl, each Y group is independently -C(R<3>)R<4>-, or up to two Y groups are -N(R<4>)-, -O- or -S- and the remaining Y groups are independently -C(R<3>)R<4>-, wherein R<3> is as defined above, one R<4> group in the structure is imidazoyl or imidazoylalkyl and the remaining R<4> groups are H or C1 to C6 alkyl, and Z is > C(R<7>)NR<2>- or > N-, wherein R<7> is any of the groups recited above for R<3>, and pharmaceutically acceptable salts thereof are ligands at histamine H3 receptors.