| 摘要 |
<p>The present invention relates to a DNA-based computer which is able to perform mathematical calculations such as addition as well as logical operations. It is based, at least in part, on the discovery that DNA molecules can be used to perform operations analogous to 'bit-flipping' in computers. This capability, referred to herein as 'molecular bit-flipping', derives from the complementary nature of DNA sequences. According to the present invention, input data are each represented by single-stranded DNA molecules. Complementary DNA sequences are incorporated such that input molecules, which bear a relationship defined by the operation, hybridize and generate one or more template DNA strands for primer extension. Primer extension, in turn, creates a result DNA molecule which represents the output data, and may be read using straightforward molecular biological techniques.</p> |
