发明名称 |
RESOLUTION OF 4-CYANO-4-(3,4-DIMETHOXYPHENYL)-5-METHYLHEXANOIC ACID |
摘要 |
A reproducible process for preparing a substantially single enantiomer (R or S) of 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexanoic acid, or an analogue thereof, thereby providing single enantiomer acid for the first time, proceeds by means of a classical salt resolution employing a resolving agent selected from an enantiomer (R or S) of a 1-arylalkylamine and (-)-quinine, and provides novel salts that are readily convertible to verapamil.
|
申请公布号 |
CA2244364(A1) |
申请公布日期 |
1997.08.14 |
申请号 |
CA19972244364 |
申请日期 |
1997.02.10 |
申请人 |
DARWIN DISCOVERY LIMITED |
发明人 |
BANNISTER, ROBIN MARK;SKEAD, BENJAMIN MARK;EVANS, GRAHAM ROBERT |
分类号 |
C07C253/34;C07C255/41;C07C255/43;(IPC1-7):C07C255/43 |
主分类号 |
C07C253/34 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|