SOLID FORMULATIONS CONTAINING TREHALOSE

摘要

A method of making solid dosage forms comprises the steps of: a) combining components comprising an amount of trehalose sufficient to act as an effective diluent in the tablets formed and an amount of an active agent such that each dosage form formed contains an effective amount of active agent and an amount of aqueous solvent sufficient to suspend or dissolve the trehalose and active agent; b) processing the product of step a) to form a powder, granules or microgranules comprising a substantially homogeneous mixture of the components; and c) forming dosage forms from the powder, granules or microgranules wherein the processing in step b) is not the S-1 process.