ESTROGEN RESPONSE ELEMENT BINDING PROTEINS AND NUCLEOTIDES ENCODING THEREFOR

摘要

The invention relates to the discovery and purification of novel estrogen response element binding proteins. Estrogen response element binding proteins are distinct from the estrogen receptor and other intracellular receptors, e.g. estrogen receptor. Estrogen response element binding proteins can interfere with the biological activity of the estrogen receptor and other related intracellular receptor proteins. One aspect of the invention is to provide purified estrogen response element binding proteins. Another aspect of the invention is to provide antibodies capable of binding to the estrogen response element binding proteins of the invention. Another aspect of the invention is to provide assays for the detection or screening of therapeutic compounds that interfere with the interaction between estrogen response element binding protein and estrogen response elements.