发明名称 |
RECOMBINANT PREPARATION OF CALCITONIN FRAGMENTS AND USE THEREOF IN THE PREPARATION OF CALCITONIN AND RELATED ANALOGS |
摘要 |
A process for the recombinant preparation of a calcitonin fragment and the use of the fragment in the preparation of calcitonin and related analogs is provided. The process includes recombinantly forming a fusion protein which includes the calcitonin fragment linked to a carbonic anhydrase. The recombinantly formed fusion protein is subsequently cleaved to produce a polypeptide which includes the calcitonin fragment. A method for producing a calcitonin carba analog which includes condensing a desaminononapeptide with the recombinantly formed calcitonin fragment is also provided.
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申请公布号 |
CA2245681(A1) |
申请公布日期 |
1997.08.14 |
申请号 |
CA19972245681 |
申请日期 |
1997.02.04 |
申请人 |
BIONEBRASKA, INC. |
发明人 |
HENRIKSEN, DENNIS B.;WAGNER, FRED W.;STOUT, JAY S.;FRANK, JULIE A.;PARTRIDGE, BRUCE E.;HOLMQUIST, BART |
分类号 |
C07K14/585;C12N9/96;C12N15/16;(IPC1-7):C12N15/16 |
主分类号 |
C07K14/585 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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