发明名称 APPLICATION OF PROSTACYCLINS FOR PREPARING A MEDICAMENT EXHIBITING ANTIMETASTATIC ACTIVITY
摘要 <p>The Eptaloprost and Cicaprost (or their salts and clathrates) may be co-administered with a thromboxane receptor (TXA2) antagonist. The daily dose is typically 1-50 (pref. 12.5) micro-g i.v. and 125-350 micro-g orally for the Cicaprost and Eptaloprost or their derivs.. The daily dose of TXA2 antagonist is 100-3000 (200-1200) mg for 4-(2-(benzenesulphonamido)- ethyl)-phenoxy acetic acid (BM 13 177). The daily dose is 1-150 (2-100) mg for (1-alpha(Z)2-beta,5-alpha-(+)-(7)-((5-((1,1-biphenyl)-4-yl)methoxy)2-(4-morpholinyl) -3-oxocyclopentyl)-4-heptanoic acid (AH 23 848), or (1-beta,2-alpha(5Z)-3-alpha,4-beta) 7-((2-(phenylamino)carbonyl) hydrazino)methyl)-7-oxabicyclo (2.2.1)-hept-2-yl)-5-heptenoic acid (SQ 29548).</p>
申请公布号 CZ282638(B6) 申请公布日期 1997.08.13
申请号 CS19900004911 申请日期 1990.10.09
申请人 SCHERING AKTIENGESELLSCHAFT 发明人 SCHNEIDER MARTIN DR.;SCHILLINGER EKKEHARD DR.
分类号 A61K31/557;(IPC1-7):A61K31/557 主分类号 A61K31/557
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