TAXOID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS

摘要

This invention relates to a taxoid of the formula (I) wherein R1 is 1-propenyl radical; R2 is a C3-C5 branched alkyl radical; R3 and R4 are independently selected from hydrogen and hydroxyl protecting groups including functional groups which increase the water solubility of the taxoid antitumor agent; R5 represents a hydrogen or a hydroxyl protecting group; R6 represents an acyl radical, which are useful as antitumor agents or their precursors. A pharmaceutical composition having antineoplastic activity comprising the compound of formula (I) and a physiologically acceptable carrier and method of treatment are also disclosed.