摘要 |
Arylidene and heteroarylidene oxindole derivatives of formula (I) <IMAGE> (I) wherein, subject to provisos, Y is a bicyclic ring system chosen from naphthalene, tetralin, quinoline and isoquinoline; R is hydrogen or an oxo (=O) group when Y is tetralin; or R is hydrogen when Y is naphthalene, quinoline or isoquinoline; each of R1 and R2 independently is hydrogen, C1-C6 alkyl or C2-C6 alkanoyl; m is zero, 1 or 2; n is zero, 1, 2 or 3; each of R3 and R4 independently is hydrogen, halogen, cyano, C1-C6 alkyl, carboxy, nitro or -NR6R7 in which each of R6 and R7 independently is hydrogen or C1-C6 alkyl; R5 is hydrogen or C1-C6 alkyl; and their pharmaceutically acceptable salts, which are useful as tyrosine kinase inhibitors.
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申请人 |
FARMITALIA CARLO ERBA S.R.L. |
发明人 |
BUZZETTI, FRANCO;LONGO, ANTONIO;BRASCA, MARIA GABRIELLA;ORZI, FABRIZIO;CRUGNOLA, ANGELO;BALLINARI, DARIO;MARIANI, MARIANGELA |