Methods of treating TNF- alpha -mediated Crohn's disease using chimeric anti-TNF antibodies

摘要

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor- alpha (TNF alpha ) and are useful in vivo for diagnosis and therapy of a number of TNF alpha -mediated pathologies and conditions, including Crohn's disease, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.