| 摘要 |
Disclosed are a benzothiazolesulfonamide derivative represented by the formula (I) or a pharmaceutically acceptable acid addition salt thereof (see fig. I) (I) wherein A represents a lower alkylene group which is unsubstituted or substituted; R1 represents a hydrogen atom or a lower alkyl group; each of R2 and R3 independently represents a hydrogen atom or a lower alkyl group, or R2 and R3 are bonded to each other to form a lower alkylene group which is unsubstituted or substituted; and R4 represents a hydrogen atom, a lower alkyl group, an amidino group, or a phenyl-substituted lower alkyl group, wherein the lower alkyl group is substituted or unsubstituted, and the phenyl group is unsubstituted or substituted with a lower alkyl group, a lower alkoxy group, a halogen atom or a methylenedioxy group; a method for preparing the same; and a pharmaceutical composition comprising the same. Each of the benzothiazolsulfonamide derivative of the formula (I) of the present invention and the acid addition salt thereof has the activity to inhibit a protein kinase, such as protein kinase C or myosin light chain kinase and, terefore, can be advantageously used as an active ingredient for a reagent for the treatment and prevention of asthma.
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