发明名称 |
SENSITIZATION OF HER2/NEU OVER-EXPRESSING CANCER CELLS TO CHEMOTHERAPEUTIC DRUGS |
摘要 |
The present invention relates to methods for the inhibition of the gene product of the neu oncogene, p185neu tyrosine kinase. Over-expression of the neu oncogene leads to chemoresistance. The methods disclosed involve the novel use of emodin in combination with chemotherapeutic drugs to treat carcinoma. Furthermore, emodin surprisingly potentiates the antineoplastic effects of the chemotherapeutic agents. The inventors propose that emodin sensitizes cancer cells such that they become amenable to treatment by chemotherapeutic drugs.
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申请公布号 |
CA2245165(A1) |
申请公布日期 |
1997.08.07 |
申请号 |
CA19972245165 |
申请日期 |
1997.01.31 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
ZHANG, LISHA;HUNG, MIEN-CHIE |
分类号 |
A61K38/00;A61K31/00;A61K31/12;A61K31/122;A61K31/135;A61K31/136;A61K31/15;A61K31/165;A61K31/166;A61K31/19;A61K31/192;A61K31/70;A61K33/24;A61K45/00;A61K45/06;A61P35/00;A61P43/00;(IPC1-7):A61K31/12 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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