发明名称 |
HUMAN DNASE RESISTANT TO ACTIN INHIBITION |
摘要 |
This invention relates to a novel human deoxyribonuclease, referred to as LS-DNase, that is relatively resistant to inhibition by actin, as compared to human DNase I. The invention provides nucleic acid sequences encoding LS-DNase, thereby enabling the production of LS-DNase by recombinant DNA methods in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and therapeutic uses of LS-DNase.
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申请公布号 |
WO9728266(A1) |
申请公布日期 |
1997.08.07 |
申请号 |
WO1997US01506 |
申请日期 |
1997.02.03 |
申请人 |
GENENTECH, INC. |
发明人 |
BAKER, KEVIN, P.;BARON, WILL, F. |
分类号 |
C12N15/09;A61K31/00;A61K38/00;A61K38/46;A61K48/00;A61P11/00;A61P29/00;A61P37/00;C07K16/40;C12N5/10;C12N9/22;C12N15/55;C12P21/08;(IPC1-7):C12N15/55 |
主分类号 |
C12N15/09 |
代理机构 |
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地址 |
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