| 摘要 |
A method for preparation of biological material for a medical device. Samples of intact or acellular tissue of biological material are treated in vitro with (i) a water-soluble carbodiimide of the formula R1-N=C=N-R2, wherein R1 and R2 are independently selected from alkyl and alkylamino groups, in combination with (ii) an agent that forms a stable activated ester with said carbodiimide. The agent to stabilize the activated esters is preferably N-hydroxysuccinimide or N-hydroxysulfosuccinimide. The preferred carbodiimide is 1-ethyl-3-(dimethylaminopropyl)-carbodiimide. The method reduces inflammatory reactions of xenografts.
|
