| 摘要 |
<p>Antitumor agents which comprise as the principal agent a mixture of organic compounds having amino and silyl groups (called silamines) and represented by structural formulae with adriamycin. Use of silamines in the form of a mixture with adriamycin, which is an anticancer agent showing a potent effect but having extremely serious side-effects, makes it possible to highly potentiate the anticancer properties of adriamycin. As a result, the dose of adriamycin can be reduced and thus its side-effects can be relatively relieved as compared with the case where it is used alone. (A)(B) wherein R1, R2, R3, R4, R5, R6, R7 and R8 represent each hydrogen or C1-10 alkyl, aryl or aralkyl, or the pair of R1 with R2 and that of R5 with R6 may be bonded via alkylene, arylene or aralkylene.</p> |
