| 摘要 |
<p>The invention comprises a method of treating a patient with a disorder, characterized by an activating mutation in the Ras proto-oncogene, comprising contacting cells of said patient with a protein having the toxic activity of Clostridium sordellii toxin LT under conditions favoring inactivating of Ras by glucosylation of Ras' threonine 35 in said cell. Said protein preferably is an immunotoxin which contains as a toxic domain the catalytic domain of toxin LT.</p> |
