摘要 |
This invention provides a compound having the formula (see fig. 1) wherein: X is phenyl which is optionally substituted; R and R1 are each, independently, hydrogen, halogen, alkyl, alkoxy, hydroxy, or trifluoromethyl; R2 is hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl; Y is a radical selected from the group consisting of (see fig. 2) (see fig. 3) R3 is independently hydrogen, alkyl, carboxy, carboalkoxy, phenyl, or carboalkyl; n = 2-4; or a pharmaceutically acceptable salt thereof, with the proviso that each R3 of Y may be the same or different which are useful as antineoplastic agents.
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申请人 |
AMERICAN CYANAMID COMPANY |
发明人 |
WISSNER, ALLAN;JOHNSON, BERNARD D.;FLOYD, MIDDLETON B., JR.;KITCHEN, DOUGLAS B. |