| 摘要 |
Heteroaryl-oxazolidinone compounds of formula (I), and their stereoisomers, stereoisomer mixtures and salts are new. R1 = CO2R2, SO2R2, CO-R3 or CO-NR4R5; R2 = phenyl or 1-7C alkyl; R3 = CF3 or 1-6C alkyl (optionally substituted by halo or CF3); R4, R5 = H, phenyl or 1-5C alkyl; A = beta -carbolin-3-yl, indolizinyl linked via the 6-membered ring, C-linked mono-, bi- or tri- cyclic aromatic heterocycle with 6-membered rings, at least one of which contains nitrogen, or a C-linked 5-membered aromatic heterocycle containing up to 3 heteroatoms (optionally benzo- or naphtho-fused) (all optionally ring-substituted by NR6R7, Q, a group of formula (a) and/or 1-3 Q'); Q' = COOH, halo, CN, mercapto, CHO, CF3, NO2, alkoxy, alkoxycarbonyl, alkylthio, acyl or alkyl (optionally substituted by OH, 1-5C alkoxy, 1-5C acyl or NR61R71); Q = 2-8C alkylphenyl, phenyl or Het (all optionally substituted by one of CONR8R9, NR10R11, NR12SO2R13, SO2NR14R15 or S(O)aR16, and/or 1-2 Q'); R6, R7, R61, R71, R10, R11 = H, 3-6C cycloalkyl, 1-5C alkyl, or phenyl; or NR6R7, NR61R71, NR10R11 = 5-6 membered, saturated heterocycle, optionally containing a second heteroatom and which may be substituted (on C or on a second N atom) by 1-3C alkyl or 1-3C acyl; R8, R9, R12, R14, R15 = H, alkyl or phenyl; R13, R16 = 1-4C alkyl, or phenyl (optionally substituted by 1-4C alkyl); a, n = 0-2; heteroatom = N, O or S; alkyl, alkoxy have 1-6C unless specified otherwise. |
