Controlled release formulation having a preformed passageway

摘要

A controlled release pharmaceutical tablet having at least one passageway, said tablet having: (a) a compressed core which comprises: (i) a medicament; (ii) an amount of a water soluble osmotic agent which is effective to cause the medicament to be delivered from said passageway in the presence of aqueous media; (iii) a water-swellable pharmaceutically acceptable polymer; and (b) a membrane coating around said core tablet which comprises a water insoluble pharmaceutically acceptable polymer.