| 发明名称 |
CTLA4 MUTANT MOLECULE AND USE THEREOF |
| 摘要 |
The invention provides CTLA4 mutant molecules as ligands for the B7 antigen. Methods are provided for expressing CTLA4 mutant molecules as soluble, functional molecules, for preparing CTLA4 mutant fusion proteins, and for using these soluble molecules to regulate T cell interactions and immune responses mediated by such interactions. <IMAGE> |
| 申请公布号 |
JPH09202800(A) |
申请公布日期 |
1997.08.05 |
| 申请号 |
JP19960210535 |
申请日期 |
1996.07.22 |
| 申请人 |
BRISTOL MYERS SQUIBB CO |
发明人 |
PIITAA ESU RINSUREE;JIEFURII EE RETSUDOBETAA;ROBAATO PIICHI |
| 分类号 |
C12N15/09;A61K38/00;C07H21/04;C07K1/22;C07K14/495;C07K14/52;C07K14/525;C07K14/53;C07K14/54;C07K14/55;C07K14/555;C07K14/705;C07K14/715;C07K14/725;C07K16/00;C07K16/18;C07K19/00;C12N5/06;C12N5/10;C12N15/12;C12P21/02;C12R1/91 |
主分类号 |
C12N15/09 |
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