| 摘要 |
This invention relates to a process for preparing taxoid derivatives of formulae II and XI: <IMAGE> (II) <IMAGE> <IMAGE> (XI) in which Ar represents an aryl radical; R1 represents a benzoyl radical or a radical R2-O-CO- in which R2 represents an unsubstituted or substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl, or saturated or unsaturated heterocyclic radical; R3 represents an unsubstituted or substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, saturated or unsaturated heterocyclic, or aryl radial, but not a phenyl radical; R4 represents a hydrogen atom and R5 represents a hydroxyl-protecting group or R4 and R5 together form a heterocyclic group; G1 represents a hydroxyl-protecting group; and G2 represents an acetyl radical or hydroxyl-protecting group; by electrolytically reducing a protected taxoid compound in an electrolyte comprising a quaternary ammonium salt which is soluble in an organic solvent or in an aqueous/organic mixture at a controlled potential.
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